The 2015 Honda Odyssey has best-in-class EPA fuel-economy ratings. Honda paid particular attention to aerodynamics when it redesigned the van, going so far as to reshape the mirror caps for smoother airflow.
Along with its cylinder-deactivation system—which can shut down two or three cylinders depending on engine load—the six-speed automatic transmission in the Odyssey helps the minivan earn 19 mpg in the city, 28 highway. These numbers are considerably better than the comparable Toyota Sienna and Chrysler Town & Country/Dodge Grand Caravan.
In short, if you need three rows of seating and want a regular, non-hybrid powertrain, the Odyssey is your most fuel-efficient pick.