The Mercedes-Benz E-Class is one of the few vehicles that covers all of the most commonly available engine types. It's powered by gas, by a combination of gas and electricity, and by diesel, with the latter two drivetrain options delivering the top estimated fuel economy.
Mileage figures are close to those of last year's model--except in the case of the new turbodiesel four, which replaces the larger-displacement turbodiesel V-6. EPA fuel economy figures weren't yet out for that engine at our latest update.
The E350 sedan rates up to 21 mpg city, 31 highway. Stepping through the all-wheel-drive versions of the four-door and wagon, and the two-door coupe brought mileage down to 20/28 mpg, a bit lower for some of the other body styles.
The high-performance E63 AMG models were rated as low as 15 mpg city, 23 mpg highway--or 15/21 for the new E63 AMG Wagon.
Given that last year's E350 BlueTEC earned 22/32-mpg fuel economy numbers, it's a good bet the new turbo four-cylinder diesel in the E250 Bluetec will hit 35 mpg on the highway cycle. In an early drive, we managed to see 38 mpg, including some aggressive, non-mindful driving; so we expect a real-world 40 mpg on the highway to be quite easily achievable.