In the 2012 model year, the Mercedes-Benz E-Class gained a new drivetrain lineup. Not only did it add direct injection to its V-6 and V-8 offerings, but it also adopted a new Hybrid version that shares the same gas-electric system grafted on the S400 Hybrid. The result is better gas mileage across the board, with the diesel E-Class still an option for those looking for even better highway fuel economy.
The Mercedes-Benz E350 badge applies to all four body styles, and as such, fuel economy varies widely. On the standard sedan, it's an EPA-rated 20 miles per gallon city, 30 miles per gallon highway, or 23 mpg combined. Stepping through the all-wheel-drive versions of the four-door, the wagon, and the two-door coupe can bring mileage down to 19/27 mpg, or 22 mpg combined in the AWD wagon.
The E350 BlueTEC turbodiesel comes only in the sedan body style, and it posts the highest highway numbers in the lineup. It's rated at 22/32 mpg, or 25 mpg combined. This year's Hybrid addition grabs the best city figures of the E-Class family, though: it's pegged at 24/30 mpg, or 26 mpg combined.
Among the V-8-powered E550 Benzes, the Cabriolet fares worst at 16/25 mpg, or 19 mpg combined. The E550 Coupe is best at 17/27 mpg, or 21 mpg combined.
Finally, if you're even reading this section, you probably aren't considering the high-performance E63 AMG models. Rated as low as 15 mpg city, 23 highway, they're guzzlers, albeit very rewarding ones.