Safety ratings aren't quite top-notch for the Murano, although it does include an impressive list of standard safety features.
For 2013, the Murano gets newly optional active-safety systems: Moving Object Detection, Blind Spot Warning, and Lane Departure Warning systems. All are included with the Platinum Edition or SL Navigation Package, and should help the visibility issues that the curvier body design introduces.
Otherwise the Murano has earned a mix of four- and five-star ratings in National Highway Traffic Safety Administration (NHTSA) testing, and mostly 'good' ratings from the Insurance Institute for Highway Safety (IIHS), except for a 'marginal' rating in the roof-strength category--related to the likelihood of rollover injury.
All the other safety equipment you'd expect in this class is standard, including anti-lock brakes, electronic stability control, front side airbags, and side-curtain bags, plus active front head restraints.
When changing lanes or backing up, outward visibility can be a bit obscured by the sloping roofline and thick rear pillar.