The E-Class is a rolling showcase of Mercedes-Benz's ability to innovate and pack more safety features than most other automakers.
For 2012, there are eleven airbags standard, including driver knee bag, and an optional side airbag for rear-seat passengers can be added. Separate active-safety systems--to detect driver drowsiness, monitor blind spots, control high beams automatically, maintain a set following distance, and help keep you in your lane--are all available, most as part of option packages.
The Insurance Institute for Highway Safety (IIHS) has tested both two-door Coupe and four-door Sedan versions of the E-Class, and both achieved top 'good' ratings in all categories, to achieve the Top Safety Pick accolade. The Cabriolet and Wagon weren't tested, but should offer similar protection. Otherwise, the NHTSA (National Highway Traffic Safety Administration) hasn't yet rated the latest E Class.