Car safety boils down to a strong vehicle and an alert driver. The Lexus LS does its part, though its excellent reputation for safety awaits updated crash tests from both of the major agencies.
In the 2011 model year, both the National Highway Traffic Safety Administration (NHTSA) and the Insurance Institute for Highway Safety (IIHS) changed the way they calculate safety ratings. As of yet, neither has refigured its rankings for the LS. Prior to the change, the LS was a top-rated vehicle by both. (The IIHS does give the LS a "good" rating for their front-impact protection systems.)
All the requisite and now-common safety technologies are present in the LS, including front side airbags, dual front knee bags, full-length side-curtain bags, and active headrests. Rear-seat side airbags are available. Lexus' flavor of stability control is intertwined with its traction control and anti-lock brakes.
Lexus now offers an Enform and Safety Connect system on subscription basis; the telematic systems notify Lexus if the vehicle is involved in an accident and summon emergency personnel automatically.
The Lexus LS also features a self-parking system that steers the vehicle into a parallel or row parking spot as the driver backs up; some will find it helpful and a safety aid, but to others it's a gimmick.