Lack of official stamp of approval aside, the R8 offers Audi's brand reputation for excellent crash safety, an extremely high-tech aluminum space frame, and a strong suite of standard safety features.
Some of those features include quattro all-wheel drive; dual front, side, and knee airbags (though not even coupes get side curtain airbags); anti-lock brakes; traction control, and stability control. The stability control has a performance mode setting that allows more fun while still reigning in unsafe impulses.
Optional extras that aren't strictly safety-related but which can aid in keeping an eye on things around the low-slung R8 include parking sensors and a rearview camera. They're standard on V-10 models, but are a definite desired feature for the V-8s, too, as they make backing up and positioning the car much easier. The optional LED headlights are also a nice extra, providing brighter, whiter light improving both visibility out of the R8 and toward it.