All the standard safety features that you might expect here come standard in the FX, and as with most luxury vehicles in this price territory, a number of (expensive) high-tech active-safety options might help you avoid an accident in the first place.
Lane Departure Prevention follows lane markings on the road, notifies the driver, and can even apply the brakes lightly, while an advanced cruise control system can bring the FX to a complete stop if traffic slows.
Visibility is of course an issue, as you might guess given the curvy body and thick rear pillars, but it's not as bad as you might think. Since the FX isn't as high as other crossovers and SUVs, so you're more at street level. Get the optional Around View Monitor, and it helps a lot with parking, showing an overhead view of the vehicle.
And there still aren't many conventional ways—like crash tests—to gauge the FX, as it's a relatively low-sales-volume vehicle. But the insurance-funded Insurance Institute for Highway Safety has given it top 'good' ratings for frontal and rear impact (although they also didn't test it for side impact).
In addition, the FX35 and FX50 have all the safety features that buyers of this type of vehicle should expect: standard front side airbags, side-curtain bags that protect outboard front and rear passengers, anti-lock brakes, and electronic stability control.