With a curb weight approaching 6,000 pounds and only a pair of gas-powered V-8 engines to choose from, the 2012 Toyota Sequoia is hardly what you would call fuel-efficient.
The most frugal model, if you can call it that, is the base SR5 version equipped with a 4.6-liter V-8 and rear-wheel drive. Its official EPA gas mileage rating is 14/20 mpg city/highway and 16 mpg combined. If you opt for the Sequoia's 5.7-liter V-8 option and all-wheel drive, you’ll see gas mileage drop to 13/17 mpg city/highway and 12 mpg combined.
Note, the bigger V-8 is E85 flex-fuel capable, but if you want to be really environmentally conscious, while still having most of the Sequoia’s capability, GM's full-size SUVs, the Chevrolet Tahoe and GMC Sierra, do offer a hybrid option, and Mercedes-Benz’s GL Class can be ordered with a clean diesel.