Even in a class that includes some of the least fuel-efficient passenger vehicles sold in America, the Nissan Titan is a laggard.
The EPA rates this year's Titan at 12/17 mpg when it's fitted with four-wheel drive, and slightly better at 13/18 mpg as a two-wheel-drive truck. In our experience, real-world gas mileage numbers will fall to the lower end of the Titan's scale.
At issue: Nissan is the only manufacturer of full-size pickups sold in the U.S. that does not offer a V-6 engine. Some of its competitors may not offer very efficient V-6s, but all of them are better on gas than the Titan. The Titan is capable of running on E85 biofuel, but that option's really only realistic in the corn belt.