If you're shopping crossover vehicles and trying to eke out better gas mileage to combat $4 fuel, the Toyota Venza isn't a bad choice.
While Ford's newest Edge has the best EPA ratings in the class, the Venza's standard four-cylinder turns in good fuel-economy numbers. It's rated at 21/27 mpg in front-drive versions, 20/25 mpg in models with all-wheel drive.
Switch to V-6 power, and the numbers fall accordingly. Front-drive, six-cylinder Venzas earn a 19/26-mpg rating, which drops to 18/25 mpg with all-wheel drive--the added traction adds weight you'll be lugging around all the time, so you'll be paying the fuel premium for the life of the vehicle.
In real-world driving, the difference in fuel economy between the two engines is likely quite small, especially if you live in hilly terrain that might tax the four-cylinder engine, or if you do a lot of highway driving.