Pickups, especially compact and mid-size models, haven't historically been as strong for safety as other types of vehicles. Although the 2010 Nissan Frontier isn't at the front of the pack in safety, it's respectable.
The 2010 Frontier has acceptable but not excellent crash-test ratings, with a mix of four- and five-star ratings in federal frontal tests and five stars in NHTSA's side test. Two-wheel-drive versions get a three-star rollover rating. In IIHS tests, the Frontier rates "good" in the frontal offset but only "poor" in the seat-based rear-impact test. The IIHS hasn't retested the Frontier since side airbags and side-curtain bags became standard.
Otherwise, the Frontier has a reasonably good safety-features list, though electronic stability control isn't offered on four-cylinder models (it's standard with the V-6). Hill Start Assist and Hill Descent Control testify to the Frontier's off-roading credentials. Cars.com reports that "all-disc antilock brakes are standard," and Car and Driver notes the "active headrests for the front seats," as well as a tire pressure monitoring system and seatbelt pretensioners.