A full set of crash-test results aren't available on the 2010 Toyota Sequoia, but it does get a five-star rating for driver-side front-impact protection, along with four stars for the front passenger from NHTSA.
The 2010 Sequoia also comes with all the expected safety equipment, including electronic stability control, side, and side curtain airbags. The Sequoia’s height and sheer size, paired with tough outward visibility, make it cumbersome to maneuver, so you might be at a disadvantage versus a smaller, nimbler vehicle in avoiding an accident in the first place.
The optional navigation system on the Sequoia includes a backup camera, but Cars.com remarks, "you can't get the feature as a lower-priced, stand-alone option without navigation, as you can on the Tundra and smaller Highlander SUV. Disappointing."
According to Car and Driver, “the Sequoia delivers, starting with standard electronic stability control and roll-sensing side curtain airbags for all three rows.”