The 2010 S-Class hasn't been crash-tested by either NHTSA (National Highway Traffic Safety Administration) or the IIHS (Insurance Institute for Highway Safety).
Still, it enjoys a long-standing reputation as one of the safest vehicles in the world. We'll revisit its high safety rating when more data is released.
The S-Class has comprehensive safety features, such as front and rear side airbags; full-length side curtain airbags; anti-lock brakes; traction and stability control; active head restraints; adaptive brake lights; and the PRE-SAFE system, which tightens seatbelts and locks doors when it senses an imminent collision and can now apply full braking force to mitigate injury and damage from accidents.
New features include Attention Assist, which detects sleepy drivers and asks them to pull over for a rest via a coffee-cup icon; Nightview Assist PLUS, which uses infrared sensors to highlight unseen objects ahead on dark roads; Lane Keeping Assist, which alerts drivers wandering out of their driving lane and nudges them gently back on track; blind-spot alerts; adaptive cruise control; and automatic high beams.
Visibility is excellent in the S-Class, though parking safety's improved with the available rearview camera and front and rear parking sensors.
Automobile: night vision "reminds me too much of the bumper camera view on a racing video game"
Cars.com: night vision can see "almost 500 feet ahead of the car and display the view in the instrument panel"
Cars.com: "Pre-Safe can ready occupants for a collision"