Because it's not subject to the same standards and testing as smaller cars, there is not much written about the safety features of the 2008 Ford Econoline series, but for the most part, expected safety features are present
All 2008 Ford Econoline vans have four-wheel anti-lock disc brakes and electronic brake force distribution as standard features, along with front seatbelt pretensioners. Edmunds.com reports that the E-350 Super Duty with the 5.4-liter V-8 "features standard AdvanceTrac stability control with a rollover avoidance system"--though NHTSA anti-rollover ratings for the 15-passenger E-350 are slightly worse (30 percent as opposed to 27 percent) than for the E-150.
Traction control is optional on models without the stability control system. Cars.com reports that suspension components have been upgraded in the 2008 Econoline, and that "the E-Series now has heavier-duty sway bars and larger brakes."
The standard crash protection features of the 2008 Econoline include second-generation driver and passenger airbags (the passenger airbag can be deactivated manually with a switch); headrests on the two front seats, anchors for child seats, and front and rear outboard three-point shoulder and lap belts are also standard. Cars.com points out that side-impact airbags are not available, and Kelley Blue Book notes that with the Econolines, Ford doesn't offer child door locks or engine immobilizers.
None of the E-series have been rated by NHTSA for frontal or side crashes.