Overall, with EPA ratings of either 19 or 20 mpg in the city and 25 to 28 on the highway, the Santa Fe is about as good on gas as a full-size sedan—typical for a mid-size crossover, though you have to keep in mind that with the Santa Fe you don't get the added flexibility of a third-row seat.
For most crossovers in this class, if you go with the smaller four-cylinder engine you'll get a greener, more fuel-efficient vehicle. But that's not so much the case here; with its base engine, you might eke out a mile or two better per gallon if you drive gently, but with all-wheel drive, the V-6 is actually slightly better on gas.
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