The 2011 Lexus GS 450h, with its sophisticated hybrid system in addition to a 292-hp, 3.5-liter V-6, can push this model to 60 mph in just 5.2 seconds. With that kind of performance, it's all the more impressive that the GS 450h returns an EPA-estimated 22 mpg city, 25 highway.
Unfortunately, over a couple of drives, our editors have never been able to replicate those EPA figured in the 450h; we've seen 19 to 20 mpg averages in mixed driving—only a mile or two per gallon better than with the GS 350.
The rest of the GS lineup is pretty unremarkable. EPA ratings range from 17 to 19 mpg in the city and 24 to 26 on the highway.
The 2011 Lexus GS 450h is a standout if you plan to do a lot of city driving; otherwise the GS lineup is unremarkable.