In Insurance Institute for Highway Safety (IIHS) testing, the ES 350 achieved top 'good' scores in frontal and side impact but a low 'marginal' for rear impact. It hasn't yet been tested in the agency's new roof-strength category. The ES 350 hasn't yet been tested under a more rigorous federal testing program introduced for model-year 2011, but in the fed's previous tests, the ES 350 was good but not top-notch, attaining five-star status for frontal and side protection, though passenger side protection was rated four stars.
That said, the list of safety features in the ES 350 is very, very good—including eight airbags, anti-lock brakes with electronic brakeforce distribution, and stability control. Rear-seat side airbags have also been added, bringing the ES 350's airbag count up to 10. All ES models additionally get the Safety Connect system, which uses cellphone technology and GPS transceivers to provide Automatic Crash Notification, Stolen Vehicle Location, emergency assistance (through an SOS button), and Roadside Assistance services. A 24-hour call center aids roadside assistance.
Adaptive Cruise Control is also available; it uses radar to keep a safe distance between the Lexus ES 350 and the vehicle ahead in the lane—and it has a Pre-Collision System that will tighten seatbelts and activate the brakes without driver input, to help lessen an anticipated impact.