The National Highway Traffic Safety Administration (NHTSA) hasn't yet tested the Murano with its revamped (and tougher) ratings system, but under the old reports it earned a four-star rating for front crash protection—actually about average under the old scale—though with a five-star rating for side-impact protection.
The Insurance Institute for Highway Safety (IIHS) has given the Murano a top rating of 'good' in frontal and side impact. The Murano had in past years achieved the IIHS Top Safety Pick Status. But for 2011, the Murano was tested by the IIHS in roof strength for the first time—related to the likelihood of injury in a rollover—and the results were near the bottom of its class, with a 'marginal' rating.
All the safety equipment you'd expect in this class is standard, including anti-lock brakes, electronic stability control, front side airbags, and side-curtain bags. Active front head restraints are also standard.
Outward visibility is about on par for this class, though as is typical the sloping roofline and thick rear pillar can cut into the view back when changing lanes or backing up.