There’s little doubt that the BMW 5-Series is one of the top rivals that Lexus has in mind with the GS sedans.
Infiniti's M sedans, the M35 and M45, are actually its closest rivals in execution.
Compared to the GS, the M35/45 has a roomier interior but a similar sporty driving feel, with powerful engines and electronic driving aids, although interior noise is a bigger issue on the M than any of these rivals.
Cadillac’s CTS is a little bit smaller and more performance-focused, with excellent handling and performance, as well as a unique interior style.
The Lexus GS models also come across as more performance-oriented than the A6, lining up more closely with the 340-horsepower, V-8-powered S6, which takes on the GS 460.
But the S6 has all-wheel drive, a feature that's not available on the GS 460 (only the 350).
The Mercedes-Benz E-Class, recently redesigned, is softer and more comfort-oriented than the 2010 GS.
For the 2010 Lexus GS 450h, its leading rival is likely the Mercedes-Benz E320 BlueTec.
With a clean-diesel engine, the BlueTec gets much better fuel economy than the 450h, and it’s the more fitting choice for long-haul highway driving.
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|2010 Lexus GS 350Browse Used Listings||2010 Audi S6Browse Used Listings||2010 BMW 5-SeriesBrowse Used Listings||2010 Cadillac CTSBrowse Used Listings||2010 INFINITI M35Browse Used Listings||2010 Mercedes-Benz E ClassBrowse Used Listings|
|18 MPG City / 26 MPG Hwy||14 MPG City / 19 MPG Hwy||15 MPG City / 28 MPG Hwy||16 MPG City / 27 MPG Hwy||16 MPG City / 25 MPG Hwy||13 MPG City / 26 MPG Hwy|
|Gas V6||Gas V10||Gas I6||Gas V6||Gas V6||Gas V6|
|Mid-Size||Midsize||Mid-Size||Mid-Size||4-door Large Car||Sub-Compact|
|4-Door Sedan RWD||4-Door Sedan Prestige||4-Door Sedan 528i RWD||4-Door Sedan 3.0L RWD||35 4-Door Sedan RWD||2-Door Coupe E 350 RWD|
|Rear Wheel Drive||All-Wheel Drive||Rear Wheel Drive||Rear Wheel Drive||Rear-Wheel Drive||Rear Wheel Drive|
|4 Door Sedan||4 Door Sedan||4 Door Sedan||4 Door Sedan||4-door Sedan||2 Door Coupe|
|Automatic w/OD||Automatic||Manual||Manual||Automatic||Automatic w/OD|
|Detailed Spec Comparison|
|2010 Lexus GS 350 vs. 2010 Audi S6||2010 Lexus GS 350 vs. 2010 BMW 5-Series||2010 Lexus GS 350 vs. 2010 Cadillac CTS||2010 Lexus GS 350 vs. 2010 INFINITI M35||2010 Lexus GS 350 vs. 2010 Mercedes-Benz E Class|